I.F. Trocóniz (1), M.J. Garrido (1), and F. Rombout (2) Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in the Paediatric Population
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C. Dansirikul(1), L.E. Friberg(1), S.B. Duffull(1), R.G. Morris(2), S.E. Tett(1) Bayesian Population Pharmacokinetic Analysis of Sirolimus
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Filip De Ridder (1), An Vermeulen (2) and Vladimir Piotrovskij (2) Modelling and simulation of the incidence of adverse events in clinical trials.
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Duffull SB(1), Waterhouse TH(2), Redman S(1), Eccleston JA(2) A real time optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics
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C. Dartois (1), C. Laveille (2), B. Tranchand (1,3), M. Tod (4), P . Girard (1,5) What is the Value of Uncertainty Parameter Estimates provided by Different Population PK Methods?
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N.Holford (1), P.Chan (1), J.Nutt (2) Disease Progression in Parkinson’s Disease – Evidence for Protective Effects of Drug Treatment
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Michael K. Smith(1), Mark F. Morris(1), Ieuan Jones(1), Andy P. Grieve(1), Keith Tan(2) An adaptive design for dose-response using the Normal Dynamic Linear Model.
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C. W. Tornøe (1,2,3), H. Agersø (1), R. V. Overgaard (2), H. A. Nielsen (2), H. Madsen (2), E. N. Jonsson (3) Stochastic differential equations in NONMEM
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Perez-Ruixo, JJ; Kimko, HC; Chow, A; Piotrovskij, V NONMEM Implementation of Cell Lifespan Models for Hematological Drug Effects
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R. H. Leary (1), R. Jelliffe (2), A. Schumitzky (2), R.E. Port (3) Accurate Maximum Likelihood Estimation for Parametric Population Analysis
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A. Lanner (1), X. Xiaonian (1), T. Donovan (2), B. Charles (1) Population Modelling of the Absolute Bioavailability and Pharmacokinetics of Phenobarbitone in Infants with Seizures
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H. Jones(1), R. Gieschke(2) Incorporating uncertainty and variability into PBPK based predictions of human PK
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JS Barrett, J Skolnik, MR Gastonguay and PC Adamson The Value of Priors and Prior Uncertainty in Clinical Trial Simulation: Case Study with Actinomycin-D in Children with Cancer
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I. Knutsson (1), L. Aarons (2), S.Callies (3) Bayesian analysis of a patient dataset using prior information from normal volunteers and from another patient group
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A. Lemenuel-Diot (1,2), C. Laveille( 2), N.Frey (2), R. Jochemsen (2), A. Mallet (1) Mixture Modelling for the Detection of Subpopulations in a Pharmacokinetic/Pharmacodynamic analysis
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Radojka Savic(1), Daniël M. Jonker(1), Thomas Kerbusch(2), Mats O. Karlsson(1) Evaluation of a transit compartment model versus a lag time model for describing drug absorption delay
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E. Niclas Jonsson Graphical display of population data
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Niels Rode Kristensen Using Stochastic Differential Equations for PK/PD Model Development
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Adeline Samson (1), Marc Lavielle (2) and France Mentré (1) Stochastic Approximation EM algorithm in nonlinear mixed effects models: an evaluation by simulation
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Al Maloney Using SAS for non-linear mixed modelling – An overview
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James Wright Adaptive dose-finding in two-dimensions: A phase 1 oncology example
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H.M. Jones(1), K. Jorga(2), T. Lavé(1) PK extrapolation from animal to man: the good, the bad and the ugly. An overview of the performance of different methods applied across the project portfolio at Roche
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Andy Grieve Adaptive Designs : Bayesian & Non-Bayesian Approaches
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